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    DIN7 exodeoxyribonuclease DIN7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851856, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DIN7
    Official Full Name
    exodeoxyribonuclease DIN7
    Primary source
    SGD:S000002671
    Locus tag
    YDR263C
    See related
    AllianceGenome:SGD:S000002671; FungiDB:YDR263C; VEuPathDB:YDR263C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DIN3
    Summary
    Enables 5'-3' DNA exonuclease activity. Involved in DNA repair. Located in mitochondrion. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See DIN7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (994242..995534, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene uncharacterized protein Neighboring gene palmitoyltransferase AKR1 Neighboring gene ubiquitin-protein ligase peroxin 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced expression of the DNA damage-inducible gene DIN7 results in increased mutagenesis of mitochondrial DNA in Saccharomyces cerevisiae. Koprowski P, et al. Mol Genet Genomics, 2003 Aug. PMID 12827502
    2. Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Ruby SW, et al. Mol Cell Biol, 1985 Jan. PMID 3920512, Free PMC Article
    3. Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter. Bui VN, et al. Int J Toxicol, 2015 Jan-Feb. PMID 25691521
    4. Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at ori5 in yeast. Ling F, et al. Nucleic Acids Res, 2013 Jun. PMID 23598996, Free PMC Article
    5. A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7. Yoshitani A, et al. Biochem Biophys Res Commun, 2008 Jan 4. PMID 17988640

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter
      Title: Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter.
    2. The results suggest that after homologous pairing, the relative activity levels of Din7 and Mhr1 modulate the preference for replication versus homologous recombination to repair double-strand-breaks at ori5.
      Title: Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at ori5 in yeast.
    3. DIN7 repression by Dun1 can be released upon DNA damage
      Title: The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage.
    4. 19-bp sequence is a novel cis-acting element that is required for the regulation of DIN7 expression in response to HU-induced DNA damage
      Title: A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7.
    5. The putative recombination genes CCE1, DIN7, and MHR1 have overlapping function with the mismatch repair homolog MSH1 in point mutation avoidance and suppression of aberrant recombination events.
      Title: Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exodeoxyribonuclease DIN7
    NP_010549.3
    • Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog, EXO1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      994242..995534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180571.3 → NP_010549.3  TPA: exodeoxyribonuclease DIN7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010549.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSP7, Q12086
      UniProtKB/TrEMBL
      A6ZYL6, B3LG27, B5VGE7, C7GS84, C8Z5H6, N1PAG6
      Conserved Domains (2) summary
      cd09857
      Location:1 → 202
      PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      cl22433
      Location:215 → 287
      H3TH_StructSpec-5'-nucleases; H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12086.1

    Gene LinkOut

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