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    ECM21 Ecm21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852173, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ECM21
    Official Full Name
    Ecm21p
    Primary source
    SGD:S000000197
    Locus tag
    YBL101C
    See related
    AllianceGenome:SGD:S000000197; FungiDB:YBL101C; VEuPathDB:YBL101C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ART2
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in cellular response to amino acid stimulus; cellular response to starvation; and ubiquitin-dependent endocytosis. Located in cytosol. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ECM21 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (24946..28299, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rtg3p Neighboring gene Sft2p Neighboring gene uncharacterized protein Neighboring gene gag protein Neighboring gene gag-pol fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions. Hart SFM, et al. Elife, 2021 Jan 27. PMID 33501915, Free PMC Article
    2. Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion. Hepowit NL, et al. J Cell Sci, 2023 Jul 15. PMID 37337792, Free PMC Article
    3. Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1. Nikko E, et al. EMBO Rep, 2008 Dec. PMID 18953286, Free PMC Article
    4. The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae. Kee Y, et al. J Biol Chem, 2006 Dec 1. PMID 17028178
    5. Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor. Schuldiner O, et al. Curr Genet, 1998 Jan. PMID 9472075

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion.
      Title: Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion.
    2. Complementary alpha-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids.
      Title: Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids.
    3. Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters, Thi7, Nrt1, and Thi72.
      Title: Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
    4. Ubp2 modulates Lys(63)-polyubiquitination of Rsp5 substrates in vivo, including ubiquitination of two newly identified Rsp5 substrates, Csr2 and Ecm21
      Title: The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ecm21p
    NP_009449.1
    • Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters; substrate of Rsp5p-mediated Lys63-polyubiquitination and Ubp2-mediated deubiquitination; promoter contains several Gcn4p binding sites required for induction in response to starvation via Gcn4p and the general amino acid control pathway; ECM21 has a paralog, CSR2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      24946..28299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178341.1 → NP_009449.1  TPA: Ecm21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPQ2, P38167
      UniProtKB/TrEMBL
      A6ZKK3, B3LNN1, C7GSE4, N1P900
      Conserved Domains (2) summary
      smart01017
      Location:585 → 648
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl02844
      Location:781 → 878
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38167.2

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