EFB1 translation elongation factor 1 subunit beta [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: EFB1
Gene description: translation elongation factor 1 subunit beta
Primary source: FungiDB:YAL003W
Locus tag: YAL003W
See related: SGD:S000000003; AllianceGenome:SGD:S000000003; VEuPathDB:YAL003W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TEF5
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of actin filament bundle assembly; regulation of translational termination; and translation. Part of eukaryotic translation elongation factor 1 complex. Orthologous to several human genes including EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EFB1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_001133.9 (142174..143160)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eEF1Bgamma co-immunoprecipitates with an essential component of ER-Golgi transport vesicles. Taken together, these results support a broader protein metabolism role for eEF1Bgamma.
Title: The eukaryotic translation elongation Factor 1Bgamma has a non-guanine nucleotide exchange factor role in protein metabolism.
The data obtained demonstrate involvement of the translation elongation factor eEF1B in modulating the functions of translation termination factors and suggest its possible role in GDP for GTP exchange on eRF3.
Title: Elongation factor eEF1B modulates functions of the release factors eRF1 and eRF3 and the efficiency of translation termination in yeast.
Coordination of eukaryotic translation elongation factor 1A (eEF1A) function in actin organization and translation elongation by the guanine nucleotide exchange factor eEF1Balpha.
Title: Coordination of eukaryotic translation elongation factor 1A (eEF1A) function in actin organization and translation elongation by the guanine nucleotide exchange factor eEF1Balpha.
Deletion of the two nonessential genes encoding eEF1Bgamma (TEF3 & TEF4) has no dramatic effects on total protein synthesis or translational fidelity. Instead, loss of each gene gives resistance to oxidative stress.
Title: The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.
Mg2+ has a role in nucleotide exchange by eEF1B alpha and there is a catalytic function of Lys-205 in displacing Mg2+ from its binding site
Title: Mg2+ and a key lysine modulate exchange activity of eukaryotic translation elongation factor 1B alpha.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maintenance of translational fidelity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translational termination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation elongation factor 1 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation elongation factor 1 complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: translation elongation factor 1 subunit beta

NP_009398.1

Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; human homolog EEF1B2 can complement yeast efb1 mutants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

142174..143160

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178150.1 → NP_009398.1 TPA: translation elongation factor 1 subunit beta [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009398.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPL3, P32471

UniProtKB/TrEMBL

A7A0G4, B3LUU2, C8Z3H5, G2W8M7, N1P7L5

Conserved Domains (2) summary

pfam00736
Location:123 → 206

EF1_GNE; EF-1 guanine nucleotide exchange domain

cl02776
Location:12 → 57

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family