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    ENA5 putative Na(+)-exporting P-type ATPase ENA5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851608, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ENA5
    Official Full Name
    putative Na(+)-exporting P-type ATPase ENA5
    Primary source
    SGD:S000002445
    Locus tag
    YDR038C
    See related
    AllianceGenome:SGD:S000002445; FungiDB:YDR038C; VEuPathDB:YDR038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable P-type potassium transmembrane transporter activity and P-type sodium transporter activity. Predicted to be involved in intracellular calcium ion homeostasis; metal ion transport; and monoatomic ion transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ENA5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (527422..530697, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein EHD3 Neighboring gene lysine--tRNA ligase KRS1 Neighboring gene Na(+)-exporting P-type ATPase ENA2 Neighboring gene Na(+)/Li(+)-exporting P-type ATPase ENA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancient evolutionary trade-offs between yeast ploidy states. Zörgö E, et al. PLoS Genet, 2013 Mar. PMID 23555297, Free PMC Article
    2. The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane. Wieland J, et al. EMBO J, 1995 Aug 15. PMID 7664728, Free PMC Article
    3. Independent Mechanisms for Acquired Salt Tolerance versus Growth Resumption Induced by Mild Ethanol Pretreatment in Saccharomyces cerevisiae. McDaniel EA, et al. mSphere, 2018 Nov 28. PMID 30487155, Free PMC Article
    4. Regulation of the Na+/K+-ATPase Ena1 Expression by Calcineurin/Crz1 under High pH Stress: A Quantitative Study. Petrezsélyová S, et al. PLoS One, 2016. PMID 27362362, Free PMC Article
    5. Potassium- or sodium-efflux ATPase, a key enzyme in the evolution of fungi. Benito B, et al. Microbiology (Reading), 2002 Apr. PMID 11932440

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type sodium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type potassium transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type sodium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type sodium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type sodium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative Na(+)-exporting P-type ATPase ENA5
    NP_010323.3
    • Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      527422..530697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180346.3 → NP_010323.3  TPA: putative Na(+)-exporting P-type ATPase ENA5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010323.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS26, E9PAF4, P89901, Q12691
      UniProtKB/TrEMBL
      C8Z4W0
      Conserved Domains (1) summary
      TIGR01523
      Location:11 → 1055
      ATPase-IID_K-Na; potassium and/or sodium efflux P-type ATPase, fungal-type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12691.1

    Gene LinkOut

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