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    ERG3 C-5 sterol desaturase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850745, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ERG3
    Official Full Name
    C-5 sterol desaturase
    Primary source
    SGD:S000004046
    Locus tag
    YLR056W
    See related
    AllianceGenome:SGD:S000004046; FungiDB:YLR056W; VEuPathDB:YLR056W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PSO6; SYR1
    Summary
    Enables C-5 sterol desaturase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum lumen. Orthologous to human SC5D (sterol-C5-desaturase). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ERG3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (253861..254958)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Osw2p Neighboring gene SAGA complex subunit SPT8 Neighboring gene putative mannosidase MNL2 Neighboring gene glycine hydroxymethyltransferase SHM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies on the delta 5-desaturation in ergosterol biosynthesis in yeast. Osumi T, et al. J Biochem, 1979 Mar. PMID 34600
    2. Structural and physiological features of sterols necessary to satisfy bulk membrane and sparking requirements in yeast sterol auxotrophs. Rodriguez RJ, et al. Arch Biochem Biophys, 1983 Sep. PMID 6354097
    3. The ERG3 gene in Saccharomyces cerevisiae is required for the utilization of respiratory substrates and in heme-deficient cells. Smith SJ, et al. Yeast, 1993 Nov. PMID 8109167
    4. Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole. Jackson CJ, et al. Biochem Biophys Res Commun, 2003 Oct 3. PMID 13679073
    5. Molecular mechanisms of itraconazole resistance in Candida dubliniensis. Pinjon E, et al. Antimicrob Agents Chemother, 2003 Aug. PMID 12878500, Free PMC Article

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables C-5 sterol desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-5 sterol desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables C-5 sterol desaturase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables delta7-sterol 5(6)-desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-5 sterol desaturase
    NP_013157.1
    • C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      253861..254958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181943.1 → NP_013157.1  TPA: C-5 sterol desaturase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013157.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY58, P32353
      UniProtKB/TrEMBL
      A7A0W1, C7GQN3, C8ZD28, G2WIP9, N1P0Z8
      Conserved Domains (1) summary
      COG3000
      Location:77 → 350
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32353.1

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