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    GAR1 H/ACA snoRNP pseudouridylase subunit GAR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856489, updated on 17-May-2024

    Summary

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    Gene symbol
    GAR1
    Gene description
    H/ACA snoRNP pseudouridylase subunit GAR1
    Primary source
    FungiDB:YHR089C
    Locus tag
    YHR089C
    See related
    SGD:S000001131; AllianceGenome:SGD:S000001131; VEuPathDB:YHR089C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables box H/ACA snoRNA binding activity. Involved in snRNA pseudouridine synthesis. Located in nucleolus. Part of box H/ACA snoRNP complex. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GAR1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (282681..283298, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rtc3p Neighboring gene rRNA-binding ribosome biosynthesis protein RPF1 Neighboring gene histone acetyltransferase YNG2 Neighboring gene arginine--tRNA ligase MSR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gar1p binds to the small nucleolar RNAs snR10 and snR30 in vitro through a nontypical RNA binding element. Bagni C, et al. J Biol Chem, 1998 May 1. PMID 9556561
    2. A small nucleolar RNP protein is required for pseudouridylation of eukaryotic ribosomal RNAs. Bousquet-Antonelli C, et al. EMBO J, 1997 Aug 1. PMID 9303321, Free PMC Article
    3. Identification of a segment of the small nucleolar ribonucleoprotein-associated protein GAR1 that is sufficient for nucleolar accumulation. Girard JP, et al. J Biol Chem, 1994 Jul 15. PMID 8034598
    4. Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. Peifer C, et al. Nucleic Acids Res, 2013 Jan. PMID 23180764, Free PMC Article
    5. A physical interaction between Gar1p and Rnt1pi is required for the nuclear import of H/ACA small nucleolar RNA-associated proteins. Tremblay A, et al. Mol Cell Biol, 2002 Jul. PMID 12052886, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studied and discovered 21 native sites of arginine methylation on five putative Hmt1 substrate proteins (Gar1p, Nop1p, Npl3p, Nsr1p, Rps2p).
      Title: Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p.
    2. box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p
      Title: The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables box H/ACA snoRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snoRNA guided rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H/ACA snoRNP pseudouridylase subunit GAR1
    NP_011957.1
    • Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      282681..283298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179219.1 → NP_011957.1  TPA: H/ACA snoRNP pseudouridylase subunit GAR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL41, P28007
      UniProtKB/TrEMBL
      A0A8H4BZR1, A6ZSZ9, B3LSK7, B5VK20, C7GWV3, C8Z9N4, G2WFG4, N1P2P9
      Conserved Domains (1) summary
      pfam04410
      Location:29 → 124
      Gar1; Gar1/Naf1 RNA binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28007.1

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