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    GLO1 lactoylglutathione lyase GLO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855009, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLO1
    Official Full Name
    lactoylglutathione lyase GLO1
    Primary source
    SGD:S000004463
    Locus tag
    YML004C
    See related
    AllianceGenome:SGD:S000004463; FungiDB:YML004C; VEuPathDB:YML004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lactoylglutathione lyase activity. Involved in glutathione metabolic process and methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GLO1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (261705..262685, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase Neighboring gene uncharacterized protein Neighboring gene Vrl1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Measuring intracellular enzyme concentrations: Assessing the effect of oxidative stress on the amount of glyoxalase I. Vicente Miranda H, et al. Biochem Mol Biol Educ, 2008 Mar. PMID 21591178
    2. Yeast glyoxalase I is a monomeric enzyme with two active sites. Frickel EM, et al. J Biol Chem, 2001 Jan 19. PMID 11050082
    3. Diffusion-dependent kinetic properties of glyoxalase I and estimates of the steady-state concentrations of glyoxalase-pathway intermediates in glycolyzing erythrocytes. Shih MJ, et al. Eur J Biochem, 1997 Mar 15. PMID 9108256
    4. Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae). Caccuri AM, et al. Biochim Biophys Acta, 1993 Sep 3. PMID 8373819
    5. Deuterium isotope effects on the product partitioning of fluoromethylglyoxal by glyoxalase I. Proof of a proton transfer mechanism. Chari RV, et al. J Biol Chem, 1981 Oct 10. PMID 7024272

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lactoylglutathione lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactoylglutathione lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    lactoylglutathione lyase GLO1
    NP_013710.1
    • Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; required for full activity of O-acetyl homoserine sulfhydrylase, Met17p; expression regulated by methylglyoxal levels and osmotic stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      261705..262685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182359.1 → NP_013710.1  TPA: lactoylglutathione lyase GLO1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZH1, P50107, Q9HFG0, Q9URB5
      UniProtKB/TrEMBL
      C7GLC1, G2WK49, N1P5A9
      Conserved Domains (1) summary
      cd07233
      Location:23 → 165
      GlxI_Zn; Glyoxalase I that uses Zn(++) as cofactor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50107.1

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