GLT1 glutamate synthase (NADH) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GLT1
Gene description: glutamate synthase (NADH)
Primary source: FungiDB:YDL171C
Locus tag: YDL171C
See related: SGD:S000002330; AllianceGenome:SGD:S000002330; VEuPathDB:YDL171C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutamate synthase (NADH) activity. Involved in ammonia assimilation cycle and glutamate biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GLT1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (149203..155640, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Improved production of ethanol by deleting FPS1 and over-expressing GLT1 in Saccharomyces cerevisiae.
Title: Improved production of ethanol by deleting FPS1 and over-expressing GLT1 in Saccharomyces cerevisiae.
Over-expressing the GLT1 gene in the presence of a glycerolphosphate dehydrogenase deletion increases ethanol production.
Title: Over-expressing GLT1 in a gpd2Delta mutant of Saccharomyces cerevisiae to improve ethanol production.
Chromatin organization plays a major role in the bidirectional properties of the UGA3-GLT1 promoter, through the action of an upstream Abf1p-binding consensus sequence and a polydAdT(tract).
Title: The UGA3-GLT1 intergenic region constitutes a promoter whose bidirectional nature is determined by chromatin organization in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables glutamate synthase (NADH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate synthase (NADH) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate synthase (NADH) activity	IEA Inferred from Electronic Annotation more info
enables glutamate synthase (NADH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-glutamate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ammonia assimilation cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonia assimilation cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutamate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: glutamate synthase (NADH)

NP_010110.1

EC 1.4.1.14

NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

149203..155640 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180231.1 → NP_010110.1 TPA: glutamate synthase (NADH) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010110.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRI0, Q12290, Q12680

UniProtKB/TrEMBL

A0A8H8UMC6, C7GL18, G2WBZ3, N1P7N3

Conserved Domains (2) summary

TIGR01317
Location:1640 → 2125

GOGAT_sm_gam; glutamate synthases, NADH/NADPH, small subunit

PRK11750
Location:41 → 1547

gltB; glutamate synthase subunit alpha; Provisional