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    GPI2 phosphatidylinositol N-acetylglucosaminyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856029, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GPI2
    Official Full Name
    phosphatidylinositol N-acetylglucosaminyltransferase
    Primary source
    SGD:S000005997
    Locus tag
    YPL076W
    See related
    AllianceGenome:SGD:S000005997; FungiDB:YPL076W; VEuPathDB:YPL076W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GCR4
    Summary
    Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GPI2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (410443..411285)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit 4 Neighboring gene uncharacterized protein Neighboring gene transcription regulator GCR1 Neighboring gene putative AAA family ATPase YTA6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homolog in Candida albicans. Yadav A, et al. Glycoconj J, 2014 Oct. PMID 25117514
    2. Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes. Schneiter R, et al. Biochem J, 2004 Aug 1. PMID 15270698, Free PMC Article
    3. A new essential gene GCR4 located in the upstream region of GCR1. Uemura H, et al. Yeast, 1995 Sep 15. PMID 7502585
    4. Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis. Newman HA, et al. Eukaryot Cell, 2005 Nov. PMID 16278447, Free PMC Article
    5. Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis. Leidich SD, et al. J Biol Chem, 1996 Nov 1. PMID 8910381

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol N-acetylglucosaminyltransferase activity IC
    Inferred by Curator
    more info
    		  
    enables phosphatidylinositol N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase
    NP_015249.1
    • Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      410443..411285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183890.1 → NP_015249.1  TPA: phosphatidylinositol N-acetylglucosaminyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015249.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3U0, P46961, P48014
      UniProtKB/TrEMBL
      A6ZWH4, B3LKZ4, B5VT86, C7GTY2, C8ZIV4, G2WPA5, N1NX81
      Conserved Domains (1) summary
      pfam06432
      Location:6 → 273
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46961.2

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