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    GRX1 dithiol glutaredoxin GRX1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850322, updated on 2-Nov-2024

    Summary

    Official Symbol
    GRX1
    Official Full Name
    dithiol glutaredoxin GRX1
    Primary source
    SGD:S000000540
    Locus tag
    YCL035C
    See related
    AllianceGenome:SGD:S000000540; FungiDB:YCL035C; VEuPathDB:YCL035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutathione peroxidase activity and glutathione transferase activity. Involved in cellular response to oxidative stress and protein glutathionylation. Located in cytoplasm and nucleus. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See GRX1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (60841..61173, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Sro9p Neighboring gene Gfd2p Neighboring gene Lsb5p Neighboring gene peptide-methionine (R)-S-oxide reductase

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein glutathionylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dithiol glutaredoxin GRX1
    NP_009895.1
    • Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      60841..61173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178680.1NP_009895.1  TPA: dithiol glutaredoxin GRX1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009895.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQY0, P25373
      UniProtKB/TrEMBL
      A6ZTF5, B3LU47, C7GSZ2, C8Z454, G2W9Z0, N1P7Z5
      Conserved Domains (1) summary
      cd03419
      Location:1992
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...