HHT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HHT2
Primary source: FungiDB:YNL031C
Locus tag: YNL031C
See related: SGD:S000004976; AllianceGenome:SGD:S000004976; VEuPathDB:YNL031C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cupric reductase activity. Involved in several processes, including cellular copper ion homeostasis; nucleic acid metabolic process; and sexual sporulation resulting in formation of a cellular spore. Located in nucleus. Part of CENP-A containing nucleosome and replication fork protection complex. Orthologous to several human genes including H3-3B (H3.3 histone B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (575640..576050, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The 80[th] Threonine Residue of Histone H3 Is Important for Maintaining HM Silencing in Saccharomyces cerevisiae.
Title: The 80(th) Threonine Residue of Histone H3 Is Important for Maintaining HM Silencing in Saccharomyces cerevisiae.
Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast.
Title: Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast.
A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
Title: A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
The authors show that yeast chromatin assembly factor 1 binding to a histone H3-H4 dimer activates the Cac1 winged helix domain interaction with DNA. This drives the formation of a transient intermediate containing two chromatin assembly factor 1 complexes, each associated with one H3-H4 dimer. Here, the (H3-H4)2 tetramer is formed and deposited onto DNA.
Title: DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication.
Here, the authors report that yeast chromatin assembly factor 1 (CAF1), a conserved histone chaperone complex that deposits H3-H4 during DNA replication, binds a single H3-H4 heterodimer in solution.
Title: Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1.
Data indicate histone post-translational modifications (PTMs) enriched at a DNA double-strand break (DSB) site.
Title: Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
We found that ectopic CENP-A(Cse4) is enriched at promoters that contain histone H2A.Z(Htz1) nucleosomes, but that H2A.Z(Htz1) is not required for CENP-A(Cse4) mislocalization
Title: Regulation of Budding Yeast CENP-A levels Prevents Misincorporation at Promoter Nucleosomes and Transcriptional Defects.
The results showed that tri-methylation of lysine 4 on histone H3 is involved in phenotypic variation with regard to ethanol tolerance with respect to classic breeding methods used in yeast.
Title: The relationship between lysine 4 on histone H3 methylation levels of alcohol tolerance genes and changes of ethanol tolerance in Saccharomyces cerevisiae.
The molecular mechanism linking double strand break sequences to chromosome axes and the importance of H3K4 methylation for meiotic recombination.
Title: Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes.
Studies identified mutations altering eight histone residues (H3 residues V46, R49, V117, Q120, and K122 and H4 residues R36, I46, and S47) that strongly increase SER3 expression without reducing the transcription of the intergenic SRG1 ncDNA.
Title: Identification of histone mutants that are defective for transcription-coupled nucleosome occupancy.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables cupric reductase (NADH) activity	IDA Inferred from Direct Assay more info	PubMed
enables cupric reductase (NADH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone H3

NP_014367.1

Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage