HIS6 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HIS6
Official Full Name: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6
Primary source: SGD:S000001282
Locus tag: YIL020C
See related: AllianceGenome:SGD:S000001282; FungiDB:YIL020C; VEuPathDB:YIL020C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity. Involved in L-histidine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See HIS6 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (314035..314820, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

X-ray structure at a resolution of 1.30 A. This model enables us to identify catalytic residues and to propose a reaction mechanism where two aspartates act as acid/base catalysts
Title: Crystal structure of the yeast His6 enzyme suggests a reaction mechanism.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	IEA Inferred from Electronic Annotation more info
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-histidine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in L-histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6

NP_012244.3

EC 5.3.1.16

Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

314035..314820 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179370.3 → NP_012244.3 TPA: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012244.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVQ9, P40545, Q6Q5P5

UniProtKB/TrEMBL

B3LTM8, B5VKS1, C7GPW8, C8ZAN0, G2WGC4, N1P0N3

Conserved Domains (1) summary

TIGR02129
Location:2 → 258

hisA_euk; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic type