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    HOS1 histone deacetylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856181, updated on 28-Oct-2024

    Summary

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    Official Symbol
    HOS1
    Official Full Name
    histone deacetylase
    Primary source
    SGD:S000006272
    Locus tag
    YPR068C
    See related
    AllianceGenome:SGD:S000006272; FungiDB:YPR068C; VEuPathDB:YPR068C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CST3
    Summary
    Enables protein lysine deacetylase activity. Involved in positive regulation of transcription by RNA polymerase II. Part of histone deacetylase complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See HOS1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (682941..684353, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene NEDD8-activating protein UBA3 Neighboring gene Isa2p Neighboring gene spermidine synthase Neighboring gene Med1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-terminal short fragment of TUP1 confers resistance to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae. Takayama S, et al. Biochem Biophys Res Commun, 2011 Jul 22. PMID 21712029
    2. Polyamines inhibit the yeast histone deacetylase. Vu QA, et al. FEBS Lett, 1987 Aug 10. PMID 3301411
    3. Hos1 is a lysine deacetylase for the Smc3 subunit of cohesin. Xiong B, et al. Curr Biol, 2010 Sep 28. PMID 20797861
    4. Hos1 deacetylates Smc3 to close the cohesin acetylation cycle. Borges V, et al. Mol Cell, 2010 Sep 10. PMID 20832720
    5. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Rundlett SE, et al. Proc Natl Acad Sci U S A, 1996 Dec 10. PMID 8962081, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smc3 deacetylation by Hos1, triggered by Scc1 cleavage, facilitates efficient dissolution of sister chromatid cohesion during early metaphase.
      Title: Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase.
    2. Hos1 deacetylates Smc3 to close the cohesin acetylation cycle.
      Title: Hos1 deacetylates Smc3 to close the cohesin acetylation cycle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein lysine deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone deacetylase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase
    NP_015393.1
    • Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      682941..684353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184165.1 → NP_015393.1  TPA: histone deacetylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015393.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W472, Q12214
      UniProtKB/TrEMBL
      B3LLC1, C7GY52, C8ZJ93, N1NWD0
      Conserved Domains (1) summary
      cd11680
      Location:5 → 390
      HDAC_Hos1; Class I histone deacetylases Hos1 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12214.1

    Gene LinkOut

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