IDP1 isocitrate dehydrogenase (NADP(+)) IDP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IDP1
Official Full Name: isocitrate dehydrogenase (NADP(+)) IDP1
Primary source: SGD:S000002224
Locus tag: YDL066W
See related: AllianceGenome:SGD:S000002224; FungiDB:YDL066W; VEuPathDB:YDL066W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables isocitrate dehydrogenase (NADP+) activity. Involved in glutamate biosynthetic process. Located in mitochondrial nucleoid. Used to study high grade glioma. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See IDP1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (334835..336121)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The S. cerevisiae (Sc) Idp1, Idp2, and Idp3 are highly similar to Homo sapiens (Hs) Idh1 and Idh2 (67, 60 and 59% amino acid identity between Sc Idp1, Idp2, and Idp3, and Hs Idh1, respectively), and the arginine residues corresponding to R100 and R132 in Hs Idh1 (Hs Idh2 R140 and R172) are conserved in the corresponding yeast orthologs
Title: Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
there is an ancillary role for IDP1 in cellular glutamate synthesis and a role for IDP2 in equilibrating and maintaining cellular levels of isocitrate and alpha-ketoglutarate
Title: Kinetic properties and metabolic contributions of yeast mitochondrial and cytosolic NADP+-specific isocitrate dehydrogenases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glyoxylate cycle	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: isocitrate dehydrogenase (NADP(+)) IDP1

NP_010217.1

EC 1.1.1.42

Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

334835..336121

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180125.1 → NP_010217.1 TPA: isocitrate dehydrogenase (NADP(+)) IDP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010217.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRT1, P21954

UniProtKB/TrEMBL

A6ZXR0, B3LGW3, B5VFK1, C7GJP4, C8Z4K3, G2WC95, N1P7R0

Conserved Domains (1) summary

PRK08299
Location:18 → 424

PRK08299; NADP-dependent isocitrate dehydrogenase