KRS1 lysine--tRNA ligase KRS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KRS1
Official Full Name: lysine--tRNA ligase KRS1
Primary source: SGD:S000002444
Locus tag: YDR037W
See related: AllianceGenome:SGD:S000002444; FungiDB:YDR037W; VEuPathDB:YDR037W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GCD5
Summary: Enables lysine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in lysyl-tRNA aminoacylation. Located in cytoplasm. Used to study Charcot-Marie-Tooth disease recessive intermediate B; autosomal recessive nonsyndromic deafness 89; hypomyelinating leukoencephalopathy; and ophthalmoplegia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See KRS1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (525440..527215)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables lysine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables lysine-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	HDA more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lysyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in lysyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in lysyl-tRNA aminoacylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysine--tRNA ligase KRS1

NP_010322.1

EC 6.1.1.6

Lysyl-tRNA synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

525440..527215

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180345.1 → NP_010322.1 TPA: lysine--tRNA ligase KRS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010322.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS25, P15180

UniProtKB/TrEMBL

A6ZY05, B3LGM8, B5VFU1, C8Z4V9

Conserved Domains (1) summary

PLN02502
Location:24 → 579

PLN02502; lysyl-tRNA synthetase