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    KTI12 Kti12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853750, updated on 17-May-2024

    Summary

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    Gene symbol
    KTI12
    Gene description
    Kti12p
    Primary source
    FungiDB:YKL110C
    Locus tag
    YKL110C
    See related
    SGD:S000001593; AllianceGenome:SGD:S000001593; VEuPathDB:YKL110C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TOT4
    Summary
    Enables chromatin binding activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytoplasm and nucleus. Orthologous to human KTI12 (KTI12 chromatin associated homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KTI12 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (228939..229880, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene multifunctional nuclease RAD27 Neighboring gene DNA-binding protein ABF1 Neighboring gene transcription factor HAP4 Neighboring gene Sld2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fungal Kti12 proteins display unusual linker regions and unique ATPase p-loops. Krutyhołowa R, et al. Curr Genet, 2020 Aug. PMID 32236652, Free PMC Article
    2. Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator. Krutyhołowa R, et al. Nucleic Acids Res, 2019 May 21. PMID 30916349, Free PMC Article
    3. Comparative analysis of the conserved functions of Arabidopsis DRL1 and yeast KTI12. Jun SE, et al. Mol Cells, 2015 Mar. PMID 25518926, Free PMC Article
    4. Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator. Mehlgarten C, et al. Toxins (Basel), 2017 Sep 5. PMID 28872616, Free PMC Article
    5. Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1. Mehlgarten C, et al. FEMS Yeast Res, 2007 Aug. PMID 17367514

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we demonstrate that Kti12 binds directly to Elongator and that ATP hydrolysis is crucial for Elongator to maintain proper tRNA anticodon modification levels in vivo
      Title: Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator.
    2. The conserved functions of Arabidopsis DRL1 and yeast KTI12 deomnstrated by genetic complementation.
      Title: Comparative analysis of the conserved functions of Arabidopsis DRL1 and yeast KTI12.
    3. close physical and functional relationship between Elongator and the highly conserved Kti12 protein
      Title: Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kti12p
    NP_012812.1
    • Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      228939..229880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179676.1 → NP_012812.1  TPA: Kti12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXH7, P34253, Q05155
      UniProtKB/TrEMBL
      A0A8H4BXV9, A6ZZK6, C7GVK0, C8ZC65, G2WHS3, N1NZR8
      Conserved Domains (1) summary
      pfam08433
      Location:3 → 309
      KTI12; Chromatin associated protein KTI12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34253.2

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