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    LYS21 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851425, updated on 22-Aug-2024

    Summary

    Official Symbol
    LYS21
    Primary source
    FungiDB:YDL131W
    Locus tag
    YDL131W
    See related
    SGD:S000002289; AllianceGenome:SGD:S000002289; VEuPathDB:YDL131W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables homocitrate synthase activity. Involved in lysine biosynthetic process via aminoadipic acid. Located in nucleus. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to several human genes including HMGCLL1 (3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (227393..228715)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Srf1p Neighboring gene cullin CDC53 Neighboring gene ATPase-binding protein Neighboring gene ribosomal protein P1B

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
     
    enables homocitrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables homocitrate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables homocitrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homocitrate synthase LYS21
    NP_010151.1
    • Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      227393..228715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180190.1NP_010151.1  TPA: homocitrate synthase LYS21 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRL8, E9P8Z7, Q12122
      UniProtKB/TrEMBL
      A6ZXJ7, B3LH22, C8Z6H2, G2WC30, N1P3Z8
      Conserved Domains (1) summary
      cd07948
      Location:37298
      DRE_TIM_HCS; Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain