U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MAK3 peptide alpha-N-acetyltransferase MAK3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856163, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MAK3
    Official Full Name
    peptide alpha-N-acetyltransferase MAK3
    Primary source
    SGD:S000006255
    Locus tag
    YPR051W
    See related
    AllianceGenome:SGD:S000006255; FungiDB:YPR051W; VEuPathDB:YPR051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAA30
    Summary
    Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation and regulation of protein localization. Part of NatC complex. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MAK3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (664960..665490)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene NAPDH-dependent diflavin reductase Neighboring gene autophagy protein ATG11 Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein Neighboring gene mitogen-activated protein kinase SMK1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC. Van Damme P, et al. J Biol Chem, 2023 Feb. PMID 36567016, Free PMC Article
    2. Localized mutagenesis and evidence for post-transcriptional regulation of MAK3. A putative N-acetyltransferase required for double-stranded RNA virus propagation in Saccharomyces cerevisiae. Tercero JC, et al. J Biol Chem, 1992 Oct 5. PMID 1339437
    3. Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes. Drazic A, et al. Biosci Rep, 2021 Mar 26. PMID 33600573, Free PMC Article
    4. Two biochemically and genetically different forms of L dsRNA of Saccharomyces cerevisiae exist: One form, L2, is correlated. El-Sherbeini M, et al. Curr Genet, 1983 Mar. PMID 24173120
    5. Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases. Osberg C, et al. Sci Rep, 2016 Aug 24. PMID 27555049, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
      Title: Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide-methionine-alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-terminal protein amino acid acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    peptide alpha-N-acetyltransferase MAK3
    NP_015376.1
    • Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, NAA30, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, NAA35; NAA60, the human NatF gene, also complements the null allele

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      664960..665490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184148.1 → NP_015376.1  TPA: peptide alpha-N-acetyltransferase MAK3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015376.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W458, Q03503
      UniProtKB/TrEMBL
      A6ZWU1, B3LLA7, B5VTK4, C7GY39, C8ZJ76, G2WPM6, N1P245
      Conserved Domains (1) summary
      COG0456
      Location:26 → 162
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03503.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools