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    MATALPHA2 homeodomain mating type protein alpha2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850406, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MATALPHA2
    Official Full Name
    homeodomain mating type protein alpha2
    Primary source
    SGD:S000000635
    Locus tag
    YCR039C
    See related
    AllianceGenome:SGD:S000000635; FungiDB:YCR039C; VEuPathDB:YCR039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALPHA2
    Summary
    Enables DNA binding activity, bending; DNA-binding transcription repressor activity, RNA polymerase II-specific; and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MATALPHA2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (199546..200178, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative ribokinase Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene Ras family guanine nucleotide exchange factor BUD5 Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene uncharacterized protein Neighboring gene Taf2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromatin structure mapping in Saccharomyces cerevisiae in vivo with DNase I. Wang X, et al. Nucleic Acids Res, 2001 May 1. PMID 11328878, Free PMC Article
    2. Targeting of E. coli beta-galactosidase to the nucleus in yeast. Hall MN, et al. Cell, 1984 Apr. PMID 6323016
    3. Corepressor-directed preacetylation of histone H3 in promoter chromatin primes rapid transcriptional switching of cell-type-specific genes in yeast. Desimone AM, et al. Mol Cell Biol, 2010 Jul. PMID 20439496, Free PMC Article
    4. Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and Engrailed proteins. Peltenburg LT, et al. Development, 1997 Mar. PMID 9056783
    5. Analysis of nucleo-cytoplasmic transport in a thermosensitive mutant of nuclear pore protein NSP1. Nehrbass U, et al. Eur J Cell Biol, 1993 Oct. PMID 8269967

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MATalpha2 (alpha2) mutants with impaired DNA binding become inaccessible to the Slx5/Slx8 pathway but are still rapidly degraded through efficient shunting to the Doa10 pathway.
      Title: DNA binding by the MATα2 transcription factor controls its access to alternative ubiquitin-modification pathways.
    2. Authors propose that competitive binding to MATalpha2 by the ubiquitylation machinery and alpha2 cofactors is balanced so that alpha2 can function in transcription repression yet be short lived enough to allow cell-type switching.
      Title: STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites.
    3. Analysis of MATalpha2 binding sites on the HO promotor that mediate repression of the HO gene.
      Title: Repression of the yeast HO gene by the MATalpha2 and MATa1 homeodomain proteins.
    4. Matalpha2 corepressors Tup1 and Ssn6 modify the in vivo degradation rate of Matalpha2.
      Title: The short-lived Matalpha2 transcriptional repressor is protected from degradation in vivo by interactions with its corepressors Tup1 and Ssn6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain mating type protein alpha2
    NP_009868.3
    • Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      199546..200178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178753.1 → NP_009868.3  TPA: homeodomain mating type protein alpha2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009868.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQV2, P01367, P01368, P0CY08, P0CY09, Q6B2C0
      UniProtKB/TrEMBL
      A6ZTM1, B3LU20, C8Z424, G2WA57
      Conserved Domains (1) summary
      smart00389
      Location:135 → 188
      HOX; Homeodomain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CY08.1
    P0CY09.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials