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    MCR1 cytochrome-b5 reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853707, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MCR1
    Gene description
    cytochrome-b5 reductase
    Primary source
    FungiDB:YKL150W
    Locus tag
    YKL150W
    See related
    SGD:S000001633; AllianceGenome:SGD:S000001633; VEuPathDB:YKL150W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cytochrome-b5 reductase activity, acting on NAD(P)H. Involved in cellular response to oxidative stress and ergosterol biosynthetic process. Located in mitochondrial intermembrane space and mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. Orthologous to human CYB5R1 (cytochrome b5 reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MCR1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (166544..167452)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase GPM1 Neighboring gene NADHX dehydratase Neighboring gene RNA lariat debranching enzyme Neighboring gene succinate dehydrogenase flavoprotein subunit SDH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016. Chen K, et al. Euro Surveill, 2017 Sep. PMID 29019312, Free PMC Article
    2. Mitochondrial NADH-cytochrome b(5) reductase plays a crucial role in the reduction of D-erythroascorbyl free radical in Saccharomyces cerevisiae. Lee JS, et al. Biochim Biophys Acta, 2001 Jul 2. PMID 11420140
    3. Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria. Haucke V, et al. Mol Cell Biol, 1997 Jul. PMID 9199337, Free PMC Article
    4. Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments. Hahne K, et al. Cell, 1994 Dec 2. PMID 8001120
    5. Re-assessment of YAP1 and MCR1 contributions to inhibitor tolerance in robust engineered Saccharomyces cerevisiae fermenting undetoxified lignocellulosic hydrolysate. Wallace-Salinas V, et al. AMB Express, 2014. PMID 25147754, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome-b5 reductase
    NP_012772.1
    • Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      166544..167452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179716.1 → NP_012772.1  TPA: cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBM9, A6ZZH2, D6VX47, P36060
      UniProtKB/TrEMBL
      A0A8H4BXR5, B3LQV1, B5VM14, C7GSN4, C8ZC25, G2WHN9, N1P2Y2
      Conserved Domains (1) summary
      cd06183
      Location:56 → 302
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36060.1

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