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    MF(ALPHA)2 Mf(Alpha)2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852791, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MF(ALPHA)2
    Official Full Name
    Mf(Alpha)2p
    Primary source
    SGD:S000003057
    Locus tag
    YGL089C
    See related
    AllianceGenome:SGD:S000003057; FungiDB:YGL089C; VEuPathDB:YGL089C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cupric ion binding activity and mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MF(ALPHA)2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (344791..345153, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Fe-S cluster-binding ATPase Neighboring gene Lif1p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene E2 ubiquitin-conjugating protein MMS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biological activity and conformational isomerism in position 9 analogues of the des-1-tryptophan,3-beta-cyclohexylalanine-alpha-factor from Saccharomyces cerevisiae. Shenbagamurthi P, et al. Biochemistry, 1985 Dec 3. PMID 3910095
    2. Prepro-alpha-factor has a cleavable signal sequence. Waters MG, et al. J Biol Chem, 1988 May 5. PMID 3283123
    3. Biological activity of the Asn-5,Arg-7 tridecapeptide encoded by MF alpha 2 of Saccharomyces cerevisiae. Raths S, et al. J Bacteriol, 1986 Dec. PMID 3536883, Free PMC Article
    4. Position 13 analogs of the tridecapeptide mating pheromone from Saccharomyces cerevisiae: design of an iodinatable ligand for receptor binding. Liu S, et al. J Pept Res, 2000 Jul. PMID 10917454
    5. Structure-function analysis of the Saccharomyces cerevisiae tridecapeptide pheromone using alanine-scanned analogs. Abel MG, et al. J Pept Res, 1998 Aug. PMID 9727865

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. determined the effects of transcriptional repressor alpha2 concentration on promoter occupancy.
      Title: A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cupric ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mating pheromone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mating pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mating pheromone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mating IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Mf(Alpha)2p
    NP_011426.1
    • Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; binds copper(II) ions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      344791..345153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180954.1 → NP_011426.1  TPA: Mf(Alpha)2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU56, P32435
      UniProtKB/TrEMBL
      A6ZU91, B3LHF4, C7GW29, C8Z8F9, G2WE11, N1P356, U3N160, U3N2M0
      Conserved Domains (2) summary
      pfam04648
      Location:87 → 99
      MF_alpha; Yeast mating factor alpha hormone
      pfam05436
      Location:1 → 80
      MF_alpha_N; Mating factor alpha precursor N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32435.1

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