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    MSH1 mismatch repair ATPase MSH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856520, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSH1
    Official Full Name
    mismatch repair ATPase MSH1
    Primary source
    SGD:S000001162
    Locus tag
    YHR120W
    See related
    AllianceGenome:SGD:S000001162; FungiDB:YHR120W; VEuPathDB:YHR120W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP-dependent activity, acting on DNA; dinucleotide insertion or deletion binding activity; and guanine/thymine mispair binding activity. Involved in mismatch repair and mitochondrial DNA repair. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MSH1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (349574..352453)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 6 Neighboring gene histone methyltransferase SET1 Neighboring gene Lsm12p Neighboring gene iron-sulfur cluster assembly protein CIA2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches. Chi NW, et al. J Biol Chem, 1994 Nov 25. PMID 7961998
    2. The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches. Chi NW, et al. J Biol Chem, 1994 Nov 25. PMID 7961999
    3. A dominant mitochondrial mutator phenotype of Saccharomyces cerevisiae conferred by msh1 alleles altered in the sequence encoding the ATP-binding domain. Koprowski P, et al. Mol Genet Genomics, 2002 Feb. PMID 11862493
    4. Mitochondrial DNA mutators. Foury F, et al. Cell Mol Life Sci, 2004 Nov. PMID 15558210
    5. The yeast MSH1 gene is not involved in DNA repair or recombination during meiosis. Sia EA, et al. DNA Repair (Amst), 2005 Feb 3. PMID 15590333

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that the role of Msh1p in BER is unlikely to be involved in the avoidance of large-scale deletions and rearrangements.
      Title: Evidence that msh1p plays multiple roles in mitochondrial base excision repair.
    2. Msh1p-enhanced homologous recombination may play an important role in the prevention of oxidative lesion-induced rearrangements of the mitochondrial genome.
      Title: Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae.
    3. The putative recombination genes CCE1, DIN7, and MHR1 have overlapping function with the mismatch repair homolog MSH1 in point mutation avoidance and suppression of aberrant recombination events.
      Title: Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae.
    4. MSH1-dependent repair represents a significant back-up to mtBER in the repair of oxidative damage in mtDNA
      Title: Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dinucleotide insertion or deletion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanine/thymine mispair binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mismatch repair ATPase MSH1
    NP_011988.1
    • DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      349574..352453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179250.1 → NP_011988.1  TPA: mismatch repair ATPase MSH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011988.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL70, P25846
      UniProtKB/TrEMBL
      B3LSN5, N1P4P5
      Conserved Domains (1) summary
      COG0249
      Location:75 → 958
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25846.2

    Gene LinkOut

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