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    MSO1 Mso1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855785, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MSO1
    Official Full Name
    Mso1p
    Primary source
    SGD:S000005332
    Locus tag
    YNR049C
    See related
    AllianceGenome:SGD:S000005332; FungiDB:YNR049C; VEuPathDB:YNR049C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ascospore-type prospore membrane formation; membrane fusion; and vesicle docking involved in exocytosis. Located in several cellular components, including cellular bud membrane; cellular bud tip; and prospore membrane. Part of SNARE complex. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MSO1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (713023..713655, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase FPK1 Neighboring gene putative aminophospholipid translocase regulatory protein Neighboring gene saccharopine dehydrogenase (NADP+, L-glutamate-forming) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions. Weber-Boyvat M, et al. Mol Biol Cell, 2013 Feb. PMID 23197474, Free PMC Article
    2. Characterization of the sec1-1 and sec1-11 mutations. Brummer MH, et al. Yeast, 2001 Dec. PMID 11748729
    3. Characterization of temperature-sensitive mutations in the yeast syntaxin 1 homologues Sso1p and Sso2p, and evidence of a distinct function for Sso1p in sporulation. Jäntti J, et al. J Cell Sci, 2002 Jan 15. PMID 11839791
    4. Mso1 is a novel component of the yeast exocytic SNARE complex. Castillo-Flores A, et al. J Biol Chem, 2005 Oct 7. PMID 16087665
    5. Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast. Knop M, et al. Mol Biol Cell, 2005 Oct. PMID 16030256, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mso1p membrane interactions are essential for correct subcellular localization of Mso1p-Sec1p complexes and for membrane fusion in Saccharomyces cerevisiae.
      Title: A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions.
    2. Mso1p is in the interface of the exocyst complex, Sec4p, and the SNARE machinery, and reveal a novel layer of molecular conservation in the exocytosis machinery.
      Title: Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast.
    3. results suggest that Mso1 is a component of the exocytic SNARE complex and a possible ortholog of the Munc13/Mint proteins
      Title: Mso1 is a novel component of the yeast exocytic SNARE complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane HDA PubMed 
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mso1p
    NP_014447.3
    • Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      713023..713655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183226.3 → NP_014447.3  TPA: Mso1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014447.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1M4, P53604
      UniProtKB/TrEMBL
      A6ZSC3, B3LPJ4, B5VR74, C7GLK8, C8ZFS8, G2WLA6, N1NY90
      Conserved Domains (1) summary
      pfam14475
      Location:31 → 70
      Mso1_Sec1_bdg; Sec1-binding region of Mso1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53604.1

    Gene LinkOut

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