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    MSR1 arginine--tRNA ligase MSR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856491, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSR1
    Official Full Name
    arginine--tRNA ligase MSR1
    Primary source
    SGD:S000001133
    Locus tag
    YHR091C
    See related
    AllianceGenome:SGD:S000001133; FungiDB:YHR091C; VEuPathDB:YHR091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable arginine-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Used to study pontocerebellar hypoplasia type 6. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MSR1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (284839..286770, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene H/ACA snoRNP pseudouridylase subunit GAR1 Neighboring gene histone acetyltransferase YNG2 Neighboring gene hexose transporter HXT4 Neighboring gene Aht1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pontocerebellar hypoplasia type 6 caused by mutations in RARS2: definition of the clinical spectrum and molecular findings in five patients. Cassandrini D, et al. J Inherit Metab Dis, 2013 Jan. PMID 22569581
    2. Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes. Tzagoloff A, et al. Eur J Biochem, 1995 Jun 1. PMID 7607232
    3. Genome-Wide Dynamic Evaluation of the UV-Induced DNA Damage Response. Silva E, et al. G3 (Bethesda), 2020 Sep 2. PMID 32732306, Free PMC Article
    4. Arginine aminoacylation identity is context-dependent and ensured by alternate recognition sets in the anticodon loop of accepting tRNA transcripts. Sissler M, et al. EMBO J, 1996 Sep 16. PMID 8890180, Free PMC Article
    5. Functional genomics analysis of the Saccharomyces cerevisiae iron responsive transcription factor Aft1 reveals iron-independent functions. Berthelet S, et al. Genetics, 2010 Jul. PMID 20439772, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginyl-tRNA aminoacylation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in mitochondrial arginyl-tRNA aminoacylation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arginine--tRNA ligase MSR1
    NP_011959.1
    • Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      284839..286770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179221.1 → NP_011959.1  TPA: arginine--tRNA ligase MSR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011959.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL43, P38714
      UniProtKB/TrEMBL
      A6ZT01, B3LSK9, B5VK21
      Conserved Domains (1) summary
      TIGR00456
      Location:69 → 643
      argS; arginyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38714.3

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