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    OAR1 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853810, updated on 3-Nov-2024

    Summary

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    Official Symbol
    OAR1
    Official Full Name
    3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)
    Primary source
    SGD:S000001538
    Locus tag
    YKL055C
    See related
    AllianceGenome:SGD:S000001538; FungiDB:YKL055C; VEuPathDB:YKL055C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity. Involved in aerobic respiration and fatty acid metabolic process. Located in mitochondrion. Used to study mitochondrial metabolism disease. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See OAR1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (335321..336157, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Nup120p Neighboring gene Tma19p Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1 Neighboring gene Mdm35p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into cofactor recognition of yeast mitochondria 3-oxoacyl-ACP reductase OAR1. Zhang Y, et al. IUBMB Life, 2013 Feb. PMID 23300157
    2. Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae. Schneider R, et al. Curr Genet, 1997 Dec. PMID 9388293
    3. Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II. Gurvitz A. J Biomed Biotechnol, 2009. PMID 20145708, Free PMC Article
    4. Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast. Gurvitz A. J Biomed Biotechnol, 2009. PMID 19746209, Free PMC Article
    5. The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2. Gurvitz A. Mol Genet Genomics, 2009 Oct. PMID 19685079, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ymtOAR1 forms a homodimer, and undergoes conformational changes upon NADPH binding to the active site.
      Title: Structural insights into cofactor recognition of yeast mitochondria 3-oxoacyl-ACP reductase OAR1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)
    NP_012868.1
    • Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      335321..336157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179621.2 → NP_012868.1  TPA: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012868.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXN2, P35731
      UniProtKB/TrEMBL
      B3LR36, B5VMA1, C7GP19, C8ZCB7, N1P0M1
      Conserved Domains (1) summary
      cd05233
      Location:7 → 275
      SDR_c; classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35731.1

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