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    OPT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853218, updated on 22-Aug-2024

    Summary

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    Official Symbol
    OPT1
    Primary source
    FungiDB:YJL212C
    Locus tag
    YJL212C
    See related
    SGD:S000003748; AllianceGenome:SGD:S000003748; VEuPathDB:YJL212C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DUG4; GSH11; HGT1
    Summary
    Enables proton-dependent oligopeptide secondary active transmembrane transporter activity. Involved in oligopeptide transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (33850..36249, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT8 Neighboring gene uncharacterized protein Neighboring gene ubiquitin-protein ligase peroxin 2 Neighboring gene Cbp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of residues critical for proton-coupled glutathione translocation in the yeast glutathione transporter, Hgt1p. Zulkifli M, et al. Biochem J, 2017 May 16. PMID 28389436
    2. Substrate specificity and mapping of residues critical for transport in the high-affinity glutathione transporter Hgt1p. Zulkifli M, et al. Biochem J, 2016 Aug 1. PMID 27252386
    3. Charged/Polar-residue scanning of the hydrophobic face of transmembrane domain 9 of the yeast glutathione transporter, hgt1p, reveals a conformationally critical region for substrate transport. Thakur A, et al. G3 (Bethesda), 2015 Mar 16. PMID 25784163, Free PMC Article
    4. The role of transmembrane domain 9 in substrate recognition by the fungal high-affinity glutathione transporters. Thakur A, et al. Biochem J, 2010 Aug 1. PMID 20477749
    5. Gln-222 in transmembrane domain 4 and Gln-526 in transmembrane domain 9 are critical for substrate recognition in the yeast high affinity glutathione transporter, Hgt1p. Kaur J, et al. J Biol Chem, 2009 Aug 28. PMID 19589778, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that protonated residues E/D135 or N710 in Hgt1p prevent substrate/glutathione from binding at high pH; mutation of these residues allows substrate/glutathione to bind in a proton-dependent manner through involvement of other residues.
      Title: Identification of residues critical for proton-coupled glutathione translocation in the yeast glutathione transporter, Hgt1p.
    2. The cysteine-free Hgt1p was nonfunctional and pointed to a critical role being played by the native cysteine residues of Hgt1p.
      Title: Differential roles played by the native cysteine residues of the yeast glutathione transporter, Hgt1p.
    3. Asn-124 in transmembrane domain 1(TMD1), Gln-222 in TMD4, Gln-526 in TMD9, and Glu-544, Arg-554, and Lys-562 in the intracellular loop are essential for the transport activity of Hgt1.
      Title: Gln-222 in transmembrane domain 4 and Gln-526 in transmembrane domain 9 are critical for substrate recognition in the yeast high affinity glutathione transporter, Hgt1p.
    4. ScOPT1 and AtOPT4 are proton-coupled OPTs with broad but distinct substrate specificities and affinities.
      Title: ScOPT1 and AtOPT4 function as proton-coupled oligopeptide transporters with broad but distinct substrate specificities.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oligopeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligopeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligopeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligopeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligopeptide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oligopeptide transporter OPT1
    NP_012323.1
    • Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      33850..36249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181645.1 → NP_012323.1  TPA: oligopeptide transporter OPT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVY3, P40897
      UniProtKB/TrEMBL
      A6ZQC8, C8ZB08
      Conserved Domains (1) summary
      TIGR00728
      Location:88 → 760
      OPT_sfam; oligopeptide transporter, OPT superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40897.1

    Gene LinkOut

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