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    PBN1 Pbn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850305, updated on 29-Jun-2024

    Summary

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    Gene symbol
    PBN1
    Gene description
    Pbn1p
    Primary source
    FungiDB:YCL052C
    Locus tag
    YCL052C
    See related
    SGD:S000000557; AllianceGenome:SGD:S000000557; VEuPathDB:YCL052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to mannosyltransferase activity. Involved in GPI anchor biosynthetic process; protein processing; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-mannosyltransferase I complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PBN1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (34143..35393, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Rdt1p Neighboring gene 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase Neighboring gene Lre1p Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pbn1p: an essential endoplasmic reticulum membrane protein required for protein processing in the endoplasmic reticulum of budding yeast. Subramanian S, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418276, Free PMC Article
    2. The PBN1 gene of Saccharomyces cerevisiae: an essential gene that is required for the post-translational processing of the protease B precursor. Naik RR, et al. Genetics, 1998 Jul. PMID 9649520, Free PMC Article
    3. Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Lai MH, et al. Yeast, 1997 Mar 15. PMID 9090049
    4. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Ashida H, et al. Mol Biol Cell, 2005 Mar. PMID 15635094, Free PMC Article
    5. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. Murley A, et al. J Cell Biol, 2015 May 25. PMID 25987606, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pbn1p is required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum (ER) and is therefore an essential chaperone-like protein in the ER of yeast
      Title: Pbn1p: an essential endoplasmic reticulum membrane protein required for protein processing in the endoplasmic reticulum of budding yeast.
    2. mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I
      Title: Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycosylphosphatidylinositol-mannosyltransferase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-mannosyltransferase I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pbn1p
    NP_009878.1
    • Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      34143..35393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178697.1 → NP_009878.1  TPA: Pbn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009878.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQW4, P25580
      UniProtKB/TrEMBL
      A0A8H4BUM5, B3LU32, C7GT07, C8Z437, G2W9X5
      Conserved Domains (1) summary
      smart00780
      Location:224 → 406
      PIG-X; PIG-X / PBN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25580.1

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