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    PCL9 Pcl9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851375, updated on 17-May-2024

    Summary

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    Gene symbol
    PCL9
    Gene description
    Pcl9p
    Primary source
    FungiDB:YDL179W
    Locus tag
    YDL179W
    See related
    SGD:S000002338; AllianceGenome:SGD:S000002338; VEuPathDB:YDL179W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of establishment or maintenance of cell polarity and regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in cellular bud neck. Part of cyclin-dependent protein kinase holoenzyme complex and incipient cellular bud site. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PCL9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (138291..139205)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATPase inhibitor Neighboring gene Ait1p Neighboring gene D-lactate dehydrogenase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for the Pcl9-Pho85 cyclin-cdk complex at the M/G1 boundary in Saccharomyces cerevisiae. Tennyson CN, et al. Mol Microbiol, 1998 Apr. PMID 9593297
    2. Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton. Lee J, et al. Curr Biol, 1998 Dec 3. PMID 9843683
    3. Activation of the Cdc42p GTPase by cyclin-dependent protein kinases in budding yeast. Sopko R, et al. EMBO J, 2007 Oct 31. PMID 17853895, Free PMC Article
    4. Swi5 controls a novel wave of cyclin synthesis in late mitosis. Aerne BL, et al. Mol Biol Cell, 1998 Apr. PMID 9529390, Free PMC Article
    5. The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p. Wang Z, et al. FEBS Lett, 2001 Oct 12. PMID 11602261

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pcl9p
    NP_010102.1
    • Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p; PCL9 has a paralog, PCL2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      138291..139205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180239.1 → NP_010102.1  TPA: Pcl9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRH3, Q12477
      UniProtKB/TrEMBL
      A0A6A5PWZ8, B3LH63, B5VF93, C8Z6C5, G2WBY6, N1P5J3
      Conserved Domains (1) summary
      cd20557
      Location:48 → 143
      CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12477.1

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