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    PEX10 ubiquitin-protein ligase peroxin 10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851858, updated on 28-Oct-2024

    Summary

    Official Symbol
    PEX10
    Official Full Name
    ubiquitin-protein ligase peroxin 10
    Primary source
    SGD:S000002673
    Locus tag
    YDR265W
    See related
    AllianceGenome:SGD:S000002673; FungiDB:YDR265W; VEuPathDB:YDR265W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAS4
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein import into peroxisome matrix; protein polyubiquitination; and proteolysis involved in protein catabolic process. Located in peroxisomal membrane. Part of peroxisomal importomer complex. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 6B and peroxisome biogenesis disorder 6A. Orthologous to human PEX10 (peroxisomal biogenesis factor 10). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

    See PEX10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (998864..999877)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene exodeoxyribonuclease DIN7 Neighboring gene palmitoyltransferase AKR1 Neighboring gene E3 ubiquitin-protein ligase HEL2 Neighboring gene iron-sulfur cluster assembly protein CIA1

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of peroxisomal importomer complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin-protein ligase peroxin 10
    NP_010551.1
    • Peroxisomal membrane E3 ubiquitin ligase; required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      998864..999877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180573.1NP_010551.1  TPA: ubiquitin-protein ligase peroxin 10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010551.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSP9, E9P8T2, Q05568
      UniProtKB/TrEMBL
      A6ZYL8, B3LG25, B5VGE9, C7GS86, C8Z5H8, N1P8I4
      Conserved Domains (1) summary
      COG5574
      Location:5337
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]