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    PHB1 prohibitin subunit PHB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853033, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PHB1
    Official Full Name
    prohibitin subunit PHB1
    Primary source
    SGD:S000003364
    Locus tag
    YGR132C
    See related
    AllianceGenome:SGD:S000003364; FungiDB:YGR132C; VEuPathDB:YGR132C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrion organization; negative regulation of proteolysis; and protein folding. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See PHB1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (755589..756452, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fhn1p Neighboring gene E2 ubiquitin-protein ligase peroxin 4 Neighboring gene CCR4-NOT core subunit CAF130

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells. Piper PW, et al. Mech Ageing Dev, 2002 Feb. PMID 11744041
    2. A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry. Back JW, et al. Protein Sci, 2002 Oct. PMID 12237468, Free PMC Article
    3. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. Nijtmans LG, et al. EMBO J, 2000 Jun 1. PMID 10835343, Free PMC Article
    4. The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Piper PW, et al. Aging Cell, 2002 Dec. PMID 12882345
    5. Prohibitins and Ras2 protein cooperate in the maintenance of mitochondrial function during yeast aging. Kirchman PA, et al. Acta Biochim Pol, 2003. PMID 14739993

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in inner mitochondrial membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inner mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prohibitin subunit PHB1
    NP_011648.3
    • Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      755589..756452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181261.3 → NP_011648.3  TPA: prohibitin subunit PHB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011648.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUR4, P40961
      UniProtKB/TrEMBL
      A6ZUE6, B3LI96, B5VJ77, C7GUG3, C8Z925, G2WEL4, N1P430
      Conserved Domains (1) summary
      cd03401
      Location:29 → 223
      SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40961.2

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