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    PLP2 Plp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854456, updated on 17-May-2024

    Summary

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    Gene symbol
    PLP2
    Gene description
    Plp2p
    Primary source
    FungiDB:YOR281C
    Locus tag
    YOR281C
    See related
    SGD:S000005807; AllianceGenome:SGD:S000005807; VEuPathDB:YOR281C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables G-protein beta/gamma-subunit complex binding activity and actin binding activity. Involved in positive regulation of transcription from RNA polymerase II promoter by pheromones and protein folding. Located in cytoplasm. Orthologous to human PDCL2 (phosducin like 2) and PDCL3 (phosducin like 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PLP2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (846269..847129, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rfm1p Neighboring gene putative serine hydrolase Neighboring gene phosphoglycerate mutase Neighboring gene Hua2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast phosducin-like protein 2 acts as a stimulatory co-factor for the folding of actin by the chaperonin CCT via a ternary complex. McCormack EA, et al. J Mol Biol, 2009 Aug 7. PMID 19501098
    2. Functional analysis of Plp1 and Plp2, two homologues of phosducin in yeast. Flanary PL, et al. J Biol Chem, 2000 Jun 16. PMID 10749875
    3. The substrate specificity of eukaryotic cytosolic chaperonin CCT. Willison KR. Philos Trans R Soc Lond B Biol Sci, 2018 Jun 19. PMID 29735743, Free PMC Article
    4. Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Wysocka M, et al. Exp Cell Res, 2004 Apr 1. PMID 15023545
    5. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Stirling PC, et al. Mol Biol Cell, 2007 Jun. PMID 17429077, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In a single ATP-driven cycle, PLP2-CCT-ACT1 complexes yield 30-fold more native actin than CCT-ACT1 complexes.
      Title: Yeast phosducin-like protein 2 acts as a stimulatory co-factor for the folding of actin by the chaperonin CCT via a ternary complex.
    2. Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2.
      Title: Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Plp2p
    NP_014924.3
    • Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      846269..847129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183700.3 → NP_014924.3  TPA: Plp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014924.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Y0, Q12017
      UniProtKB/TrEMBL
      A0A8H4F8X5, A6ZPB7, C7GWB0, G2WNE8, N1P3N0
      Conserved Domains (1) summary
      cd02988
      Location:17 → 225
      Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12017.1

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