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    PMT6 dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853113, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PMT6
    Official Full Name
    dolichyl-phosphate-mannose-protein mannosyltransferase PMT6
    Primary source
    SGD:S000003431
    Locus tag
    YGR199W
    See related
    AllianceGenome:SGD:S000003431; FungiDB:YGR199W; VEuPathDB:YGR199W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PMT6 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (897502..899781)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sng1p Neighboring gene Ypp1p Neighboring gene Elongator subunit ELP2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae. Hirayama H, et al. J Biochem, 2008 Apr. PMID 18182384
    2. Protein-O-glycosylation in yeast: protein-specific mannosyltransferases. Gentzsch M, et al. Glycobiology, 1997 Jun. PMID 9184828
    3. Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs. Guerreiro P, et al. Yeast, 1996 Mar 15. PMID 8904340
    4. Functional and genomic analyses of blocked protein O-mannosylation in baker's yeast. Arroyo J, et al. Mol Microbiol, 2011 Mar. PMID 21231968
    5. Genes involved in protein glycosylation determine the activity and cell internalization of the antifungal peptide PAF26 in Saccharomyces cerevisiae. Harries E, et al. Fungal Genet Biol, 2013 Sep-Oct. PMID 23942187

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-phosphate-mannose-protein mannosyltransferase PMT6
    NP_011715.1
    • Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      897502..899781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181328.1 → NP_011715.1  TPA: dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUY1, P42934
      UniProtKB/TrEMBL
      B3LI38, C7GRN1, C8Z992, N1P495
      Conserved Domains (1) summary
      COG1928
      Location:44 → 759
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42934.1

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