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    PPM1 leucine carboxy methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852045, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PPM1
    Official Full Name
    leucine carboxy methyltransferase
    Primary source
    SGD:S000002843
    Locus tag
    YDR435C
    See related
    AllianceGenome:SGD:S000002843; FungiDB:YDR435C; VEuPathDB:YDR435C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein C-terminal leucine carboxyl O-methyltransferase activity. Involved in C-terminal protein methylation; cellular protein-containing complex assembly; and regulation of autophagy. Orthologous to human LCMT1 (leucine carboxyl methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PPM1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1332983..1333969, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mRNA-binding protein NPL3 Neighboring gene GPI-anchor transamidase GPI17 Neighboring gene salt homeostasis regulator Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A. Laxman S, et al. Autophagy, 2014 Feb. PMID 24362312, Free PMC Article
    2. Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity. Leulliot N, et al. J Biol Chem, 2004 Feb 27. PMID 14660564
    3. Influence of genotype and nutrition on survival and metabolism of starving yeast. Boer VM, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18456835, Free PMC Article
    4. Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. Suzuki Y, et al. Nucleic Acids Res, 2009 May. PMID 19287006, Free PMC Article
    5. Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A. Li Y, et al. J Virol, 2008 Apr. PMID 18216111, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein C-terminal leucine carboxyl O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein C-terminal leucine carboxyl O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein C-terminal leucine carboxyl O-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in C-terminal protein methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine carboxy methyltransferase
    NP_010723.1
    • Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1332983..1333969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180743.1 → NP_010723.1  TPA: leucine carboxy methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT62, Q04081
      UniProtKB/TrEMBL
      B3LFM4, B5VGW6, C7GTN9, N1P788
      Conserved Domains (1) summary
      pfam04072
      Location:5 → 220
      LCM; Leucine carboxyl methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04081.1

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