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    PPS1 tyrosine/serine/threonine protein phosphatase PPS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852579, updated on 17-May-2024

    Summary

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    Gene symbol
    PPS1
    Gene description
    tyrosine/serine/threonine protein phosphatase PPS1
    Primary source
    FungiDB:YBR276C
    Locus tag
    YBR276C
    See related
    SGD:S000000480; AllianceGenome:SGD:S000000480; VEuPathDB:YBR276C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tyrosine/serine/threonine phosphatase activity. Involved in nuclear DNA replication and protein dephosphorylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PPS1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (757620..760043, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase CHK1 Neighboring gene DNA-binding protein RIF1 Neighboring gene DNA polymerase epsilon noncatalytic subunit Neighboring gene Paf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle. Ernsting BR, et al. J Biol Chem, 1997 Apr 4. PMID 9083070
    2. Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae. Kabir MA, et al. FEMS Yeast Res, 2008 Dec. PMID 18680526
    3. A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. Gazy I, et al. G3 (Bethesda), 2013 May 20. PMID 23704284, Free PMC Article
    4. Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S, et al. Science, 2010 Dec 3. PMID 21127252, Free PMC Article
    5. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine/serine/threonine protein phosphatase PPS1
    NP_009835.3
    • Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      757620..760043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178624.3 → NP_009835.3  TPA: tyrosine/serine/threonine protein phosphatase PPS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009835.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQS2, P38148
      UniProtKB/TrEMBL
      A0A8H4BTS0, A6ZLL5, B5VEM2, N1P9N4
      Conserved Domains (1) summary
      cd14516
      Location:580 → 779
      DSP_fungal_PPS1; dual specificity phosphatase domain of fungal dual specificity protein phosphatase PPS1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38148.1

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