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    PRE7 proteasome core particle subunit beta 6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852239, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PRE7
    Official Full Name
    proteasome core particle subunit beta 6
    Primary source
    SGD:S000000137
    Locus tag
    YBL041W
    See related
    AllianceGenome:SGD:S000000137; FungiDB:YBL041W; VEuPathDB:YBL041W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PRS3
    Summary
    Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Part of proteasome core complex, beta-subunit complex. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See PRE7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (141247..141972)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ecm13p Neighboring gene uridine permease Neighboring gene Erd2p Neighboring gene Min6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PRS3 encoding an essential subunit of yeast proteasomes homologous to mammalian proteasome subunit C5. Lee DH, et al. Biochem Biophys Res Commun, 1992 Jan 31. PMID 1734860
    2. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Beaupere C, et al. Proc Natl Acad Sci U S A, 2018 Sep 18. PMID 30185560, Free PMC Article
    3. Expression attenuation as a mechanism of robustness against gene duplication. Ascencio D, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33526669, Free PMC Article
    4. The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study. Groll M, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500111, Free PMC Article
    5. Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes. Kao A, et al. Mol Cell Proteomics, 2011 Jan. PMID 20736410, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasomal ubiquitin-independent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex, beta-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome core particle subunit beta 6
    NP_009512.1
    • Beta 6 subunit of the 20S proteasome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      141247..141972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178281.1 → NP_009512.1  TPA: proteasome core particle subunit beta 6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009512.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPV7, P23724
      UniProtKB/TrEMBL
      A6ZKQ5, B3LNI0, B5VDU3, C7GNC1, C8Z3Q6, G2W8W6, N1P9Q3
      Conserved Domains (1) summary
      cd03757
      Location:21 → 241
      proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23724.1

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