U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PRO2 glutamate-5-semialdehyde dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854501, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PRO2
    Official Full Name
    glutamate-5-semialdehyde dehydrogenase
    Primary source
    SGD:S000005850
    Locus tag
    YOR323C
    See related
    AllianceGenome:SGD:S000005850; FungiDB:YOR323C; VEuPathDB:YOR323C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutamate-5-semialdehyde dehydrogenase activity. Involved in proline biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Oct 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PRO2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (921535..922905, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 Neighboring gene Ldb19p Neighboring gene Frt1p Neighboring gene myosin 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. L-proline accumulation and freeze tolerance of Saccharomyces cerevisiae are caused by a mutation in the PRO1 gene encoding gamma-glutamyl kinase. Morita Y, et al. Appl Environ Microbiol, 2003 Jan. PMID 12513997, Free PMC Article
    2. Pro-oxidant action of diphenyl diselenide in the yeast Saccharomyces cerevisiae exposed to ROS-generating conditions. Moreira Rosa R, et al. Life Sci, 2005 Sep 23. PMID 15932762
    3. Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. Tomenchok DM, et al. J Bacteriol, 1987 Dec. PMID 2824433, Free PMC Article
    4. A genetic investigation of the essential role of glutathione: mutations in the proline biosynthesis pathway are the only suppressors of glutathione auxotrophy in yeast. Spector D, et al. J Biol Chem, 2001 Mar 9. PMID 11084050
    5. Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae. Mukai Y, et al. Microb Cell, 2019 Sep 24. PMID 31646149, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-5-semialdehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-5-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutamate-5-semialdehyde dehydrogenase
    NP_014968.1
    • Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      921535..922905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183743.1 → NP_014968.1  TPA: glutamate-5-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014968.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W321, P54885
      UniProtKB/TrEMBL
      A6ZPF6, B3LJY5, C7GNU0, C8ZH74, G2WNI8, N1NW80
      Conserved Domains (1) summary
      TIGR00407
      Location:11 → 422
      proA; gamma-glutamyl phosphate reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54885.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous