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    PRO3 pyrroline-5-carboxylate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856744, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRO3
    Official Full Name
    pyrroline-5-carboxylate reductase
    Primary source
    SGD:S000000825
    Locus tag
    YER023W
    See related
    AllianceGenome:SGD:S000000825; FungiDB:YER023W; VEuPathDB:YER023W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ORE2
    Summary
    Enables pyrroline-5-carboxylate reductase activity. Involved in proline biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1); PYCR2 (pyrroline-5-carboxylate reductase 2); and PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PRO3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (201076..201936)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN3 Neighboring gene Srb4p Neighboring gene carnitine O-acetyltransferase YAT2 Neighboring gene translation initiation factor eIF2 subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and sequence analysis of the cDNA encoding delta 1-pyrroline-5-carboxylate reductase from Zalerion arboricola. Kelly R, et al. Gene, 1996 Jun 12. PMID 8654976
    2. Subcellular compartmentation in control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiae. Brandriss MC, et al. J Bacteriol, 1981 Mar. PMID 7009582, Free PMC Article
    3. Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase. Brandriss MC, et al. J Bacteriol, 1992 Jun. PMID 1592829, Free PMC Article
    4. The Cdc25/Ras/cAMP-dependent protein kinase A signaling pathway regulates proline utilization in wine yeast Saccharomyces cerevisiae under a wine fermentation model. Nishimura A, et al. Biosci Biotechnol Biochem, 2022 Aug 24. PMID 35749464
    5. ore2, a mutation affecting proline biosynthesis in the yeast Saccharomyces cerevisiae, leads to a cdc phenotype. Neuville P, et al. Mol Gen Genet, 1992 Aug. PMID 1508147

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyrroline-5-carboxylate reductase
    NP_010940.3
    • Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      201076..201936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178914.3 → NP_010940.3  TPA: pyrroline-5-carboxylate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010940.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLS2, P32263
      UniProtKB/TrEMBL
      A6ZQX2, B3LS36, C7GTD5, C8Z724, G2WCQ6, N1P5I0
      Conserved Domains (1) summary
      COG0345
      Location:2 → 284
      ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32263.1

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