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    PRP42 mRNA splicing protein PRP42 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851821, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRP42
    Official Full Name
    mRNA splicing protein PRP42
    Primary source
    SGD:S000002643
    Locus tag
    YDR235W
    See related
    AllianceGenome:SGD:S000002643; FungiDB:YDR235W; VEuPathDB:YDR235W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MUD16; SNU65
    Summary
    Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U1 snRNP and U2-type prespliceosome. Orthologous to human PRPF39 (pre-mRNA processing factor 39). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PRP42 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (933504..935138)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rtn1p Neighboring gene homoaconitate hydratase LYS4 Neighboring gene riboflavin kinase Neighboring gene mitochondrial 54S ribosomal protein YmL7/YmL5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast pre-mRNA splicing requires a pair of U1 snRNP-associated tetratricopeptide repeat proteins. McLean MR, et al. Mol Cell Biol, 1998 Jan. PMID 9418882, Free PMC Article
    2. Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast. Kotovic KM, et al. Mol Cell Biol, 2003 Aug. PMID 12897147, Free PMC Article
    3. QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. Yang Y, et al. PLoS Genet, 2013. PMID 23966873, Free PMC Article
    4. Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase (Tgs1p). Boon KL, et al. FEBS Lett, 2010 Aug 4. PMID 20621096
    5. A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction. Hage R, et al. Mol Cell Biol, 2009 Jul. PMID 19451230, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to pre-mRNA 5'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 5'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA splicing protein PRP42
    NP_010521.1
    • U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      933504..935138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180543.1 → NP_010521.1  TPA: mRNA splicing protein PRP42 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSL6, Q03776
      UniProtKB/TrEMBL
      C7GVB8, N1P6X1
      Conserved Domains (1) summary
      COG5107
      Location:56 → 183
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03776.1

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