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    PUS2 pseudouridine synthase PUS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852817, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PUS2
    Official Full Name
    pseudouridine synthase PUS2
    Primary source
    SGD:S000003031
    Locus tag
    YGL063W
    See related
    AllianceGenome:SGD:S000003031; FungiDB:YGL063W; VEuPathDB:YGL063W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Located in mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PUS2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (383654..384766)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene ATP-dependent RNA helicase Neighboring gene pyruvate carboxylase 1 Neighboring gene Duo1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:Psi27/28-synthase. Behm-Ansmant I, et al. RNA, 2007 Oct. PMID 17684231, Free PMC Article
    2. Lithium Chloride Sensitivity in Yeast and Regulation of Translation. Hajikarimlou M, et al. Int J Mol Sci, 2020 Aug 10. PMID 32785068, Free PMC Article
    3. An investigation into eukaryotic pseudouridine synthases. King RD, et al. J Bioinform Comput Biol, 2014 Aug. PMID 25152040
    4. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Carlile TM, et al. Nature, 2014 Nov 6. PMID 25192136, Free PMC Article
    5. Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Schwartz S, et al. Cell, 2014 Sep 25. PMID 25219674, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial tRNA pseudouridine(27/28) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables pseudouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA pseudouridine synthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pseudouridine synthase PUS2
    NP_011452.4
    • Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      383654..384766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180928.4 → NP_011452.4  TPA: pseudouridine synthase PUS2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011452.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU78, P53167, Q06713
      UniProtKB/TrEMBL
      A6ZUB3, B3LHD2, C7GW47, C8Z8I3, N1P5H6
      Conserved Domains (1) summary
      cd02568
      Location:1 → 308
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53167.4

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