RIM11 serine/threonine protein kinase RIM11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RIM11
Gene description: serine/threonine protein kinase RIM11
Primary source: FungiDB:YMR139W
Locus tag: YMR139W
See related: SGD:S000004747; AllianceGenome:SGD:S000004747; VEuPathDB:YMR139W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GSK3; MDS1
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including ascospore formation; cellular response to heat; and cellular response to salt stress. Located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RIM11 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (546125..547237)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes.
Title: Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes.
Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
Title: Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
We also present evidence that indicates Rim11/Ume6 works independently but in parallel with that of checkpoint inhibition, dNTP regulation, and sister-chromatid recombination. In conclusion, our results establish Rim11, Ume6, the histone deacetylase complex Sin3-Rpd3 and Sml1 as new factors important in the events of faulty lagging strand synthesis.
Title: GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2.
Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2
Title: Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2.
This review summarizes the cellular roles of four homologs of GSK-3beta, RIM11, MCK1, MRK1 and YGK3, their mode of regulation, and the signals that they transmit.
Title: The Saccharomyces cerevisiae GSK-3 beta homologs.
GSK-3 is required for optimal myo-inositol-3 phosphate synthase activity and de novo inositol biosynthesis
Title: Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ascospore formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine protein kinase RIM11

NP_013859.1

EC 2.7.11.1

Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

546125..547237

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182641.1 → NP_013859.1 TPA: serine/threonine protein kinase RIM11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013859.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZW2, P38615, Q6Q5K4

UniProtKB/TrEMBL

A0A6L0ZE44, A6ZMJ9, B3LM27, C7GU79, C8ZEZ5, G2WKJ1

Conserved Domains (1) summary

cd14137
Location:34 → 325

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3