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    RPL35B ribosomal 60S subunit protein L35B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851419, updated on 3-Nov-2024

    Summary

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    Official Symbol
    RPL35B
    Official Full Name
    ribosomal 60S subunit protein L35B
    Primary source
    SGD:S000002295
    Locus tag
    YDL136W
    See related
    AllianceGenome:SGD:S000002295; FungiDB:YDL136W; VEuPathDB:YDL136W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SOS2
    Summary
    Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 19. Orthologous to human RPL35 (ribosomal protein L35). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPL35B in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (217600..218367)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glucose sensor Neighboring gene Arf family GTPase ARF2 Neighboring gene Rdi1p Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribosomal protein L35 is required for 27SB pre-rRNA processing in Saccharomyces cerevisiae. Babiano R, et al. Nucleic Acids Res, 2010 Aug. PMID 20392820, Free PMC Article
    2. Analysis of a 26,756 bp segment from the left arm of yeast chromosome IV. Wölfl S, et al. Yeast, 1996 Dec. PMID 8972577
    3. Affinity purification of ribosomes to access the translatome. Halbeisen RE, et al. Methods, 2009 Jul. PMID 19398006
    4. Quantitative proteomic analysis of ribosomal protein L35b mutant of Saccharomyces cerevisiae. Song YB, et al. Biochim Biophys Acta, 2010 Apr. PMID 19879384
    5. Monosome formation during translation initiation requires the serine/arginine-rich protein Npl3. Baierlein C, et al. Mol Cell Biol, 2013 Dec. PMID 24100011, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified 22 upregulated and 20 downregulated proteins in the rpl35bDelta mutant
      Title: Quantitative proteomic analysis of ribosomal protein L35b mutant of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L35B
    NP_010090.1
    • Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      217600..218367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180251.2 → NP_010090.1  TPA: ribosomal 60S subunit protein L35B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRG2, P0CX84, P0CX85, P39741, P39930
      UniProtKB/TrEMBL
      A6ZXE1, A6ZXJ1, C8Z6B2, G2WBX5
      Conserved Domains (1) summary
      COG0255
      Location:3 → 68
      RpmC; Ribosomal protein L29 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX84.1
    P0CX85.1

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