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    RPS28A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854338, updated on 22-Aug-2024

    Summary

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    Official Symbol
    RPS28A
    Primary source
    FungiDB:YOR167C
    Locus tag
    YOR167C
    See related
    SGD:S000005693; AllianceGenome:SGD:S000005693; VEuPathDB:YOR167C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPS33A
    Summary
    A structural constituent of ribosome. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and rRNA export from nucleus. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (648804..649007, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dynamin-like GTPase SEY1 Neighboring gene mRNA-processing endoribonuclease Neighboring gene glutamine--tRNA ligase Neighboring gene sphinganine kinase LCB4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene. Lascaris RF, et al. Nucleic Acids Res, 2000 Mar 15. PMID 10684934, Free PMC Article
    2. Transcription activation of yeast ribosomal protein genes requires additional elements apart from binding sites for Abf1p or Rap1p. Gonçalves PM, et al. Nucleic Acids Res, 1995 May 11. PMID 7784199, Free PMC Article
    3. Yeast ribosomal protein S33 is encoded by an unsplit gene. Leer RJ, et al. Nucleic Acids Res, 1983 Nov 25. PMID 6196722, Free PMC Article
    4. Dissection of Dom34-Hbs1 reveals independent functions in two RNA quality control pathways. van den Elzen AM, et al. Nat Struct Mol Biol, 2010 Dec. PMID 21102444
    5. Ribosomal protein gene transcription in Saccharomyces cerevisiae shows a biphasic response to nutritional changes. Griffioen G, et al. Microbiology (Reading), 1996 Aug. PMID 8760940

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S28A
    NP_014810.1
    • Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      648804..649007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183586.1 → NP_014810.1  TPA: ribosomal 40S subunit protein S28A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2M5, P02380, Q3E7X9
      UniProtKB/TrEMBL
      A6ZP12, B3LJK0, C7GN57, C8ZGS8, G2WN40, N1NVT8
      Conserved Domains (1) summary
      cd04457
      Location:8 → 67
      S1_S28E; S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E7X9.1

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