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    RRP45 exosome non-catalytic core subunit RRP45 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851874, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RRP45
    Official Full Name
    exosome non-catalytic core subunit RRP45
    Primary source
    SGD:S000002688
    Locus tag
    YDR280W
    See related
    AllianceGenome:SGD:S000002688; FungiDB:YDR280W; VEuPathDB:YDR280W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in RNA metabolic process. Located in nucleolus. Part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1D. Orthologous to human EXOSC9 (exosome component 9). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See RRP45 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1020747..1021664)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene Rnh202p Neighboring gene Phm6p Neighboring gene Mrx10p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of the three distal S1 motifs of Saccharomyces cerevisiae Rrp5p abolishes pre-rRNA processing at site A(2) without reducing the production of functional 40S subunits. Vos HR, et al. Eukaryot Cell, 2004 Dec. PMID 15590824, Free PMC Article
    2. The archaeal exosome core is a hexameric ring structure with three catalytic subunits. Lorentzen E, et al. Nat Struct Mol Biol, 2005 Jul. PMID 15951817
    3. Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes. Šoštarić N, et al. Mol Cell Proteomics, 2018 Dec. PMID 30181345, Free PMC Article
    4. In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae. Sterrett MC, et al. G3 (Bethesda), 2023 Aug 9. PMID 36861343, Free PMC Article
    5. Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Zenklusen D, et al. Mol Cell Biol, 2002 Dec. PMID 12417727, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TRAMP-dependent tRNA surveillance pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in TRAMP-dependent tRNA surveillance pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U1 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U1 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U4 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U4 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U5 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U5 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exosome non-catalytic core subunit RRP45
    NP_010566.1
    • Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1020747..1021664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180588.1 → NP_010566.1  TPA: exosome non-catalytic core subunit RRP45 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSR0, Q05636
      UniProtKB/TrEMBL
      A6ZYM9, B3LG14, C7GUC9, C8Z5J3, G2WB19, N1P550
      Conserved Domains (1) summary
      cd11368
      Location:7 → 278
      RNase_PH_RRP45; RRP45 subunit of eukaryotic exosome
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05636.1

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