SAE3 Sae3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SAE3
Official Full Name: Sae3p
Primary source: SGD:S000001957
Locus tag: YHR079C-A
See related: AllianceGenome:SGD:S000001957; FungiDB:YHR079C-A; VEuPathDB:YHR079C-A
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YHR079C-B
Summary: Involved in meiotic DNA recombinase assembly and reciprocal meiotic recombination. Located in condensed nuclear chromosome. Orthologous to human SWI5 (SWI5 homologous recombination repair protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SAE3 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 2

Sequence:: Chromosome: VIII; NC_001140.6 (262192..262553, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
Title: The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
Study provides evidence that both Hop2 and Sae3 promote homolog bias through a Dmc1-mediated double-strand break repair during meiosis.
Title: Hop2 and Sae3 Are Required for Dmc1-Mediated Double-Strand Break Repair via Homolog Bias during Meiosis.
show the Mei5-Sae3 complex preferentially binds a fork-like DNA substrate to 3' overhanging DNA, single-stranded DNA or double-stranded DNA
Title: The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure.
tgs1Delta cells are specifically defective in splicing SAE3 meiotic pre-mRNAs.
Title: An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs.
Mei5-Sae3 is a mediator of Dmc1 assembly during meiotic recombination in S. cerevisiae.
Title: The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae.
Sae3 and the meiotic protein Mei5 are loading factors for the RecA homolog Dmc1 recombinase and the Dmc1-Mei5-Sae3 complex is integrated onto Rad51 ensembles and plays both catalytic and structural roles in interhomolog recombination during meiosis.
Title: A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA recombinase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic DNA recombinase assembly involved in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic joint molecule formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Swi5-Sfr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Swi5-Swi2 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sae3p

NP_011947.2

Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p