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    SCJ1 Scj1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855254, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SCJ1
    Official Full Name
    Scj1p
    Primary source
    SGD:S000004827
    Locus tag
    YMR214W
    See related
    AllianceGenome:SGD:S000004827; FungiDB:YMR214W; VEuPathDB:YMR214W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-folding chaperone binding activity. Involved in ERAD pathway; protein folding in endoplasmic reticulum; and response to unfolded protein. Located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SCJ1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (695350..696483)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Efr3p Neighboring gene Cef1p Neighboring gene putative 1,3-beta-glucanosyltransferase Neighboring gene serine/threonine protein kinase SKY1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of ER resident proteins in Saccharomyces cerevisiae: implementation of H/KDEL retrieval sequences. Young CL, et al. Traffic, 2013 Apr. PMID 23324027, Free PMC Article
    2. A homologue of the bacterial heat-shock gene DnaJ that alters protein sorting in yeast. Blumberg H, et al. Nature, 1991 Feb 14. PMID 2000136
    3. Cer1p, a novel Hsp70-related protein required for posttranslational endoplasmic reticulum translocation in yeast. Hamilton TG, et al. J Biol Chem, 1996 Nov 29. PMID 8940034
    4. The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion. Nishikawa S, et al. J Biol Chem, 1997 May 16. PMID 9148890
    5. Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation. Nishikawa SI, et al. J Cell Biol, 2001 May 28. PMID 11381090, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Scj1p
    NP_013941.2
    • One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      695350..696483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182721.1 → NP_013941.2  TPA: Scj1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013941.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W039, P25303
      UniProtKB/TrEMBL
      A6ZMS6, B3LMA2, B5VPY1, C7GRD7, C8ZF78, G2WKS1, N1P0I9
      Conserved Domains (1) summary
      COG0484
      Location:21 → 377
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25303.2

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