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    SEN54 tRNA splicing endonuclease subunit SEN54 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856022, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SEN54
    Gene description
    tRNA splicing endonuclease subunit SEN54
    Primary source
    FungiDB:YPL083C
    Locus tag
    YPL083C
    See related
    SGD:S000006004; AllianceGenome:SGD:S000006004; VEuPathDB:YPL083C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to tRNA-intron endonuclease activity. Involved in tRNA-type intron splice site recognition and cleavage. Located in mitochondrial outer membrane. Part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SEN54 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (396702..398105, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Sec16p Neighboring gene Bro1p Neighboring gene DNA-binding ATPase Neighboring gene ribosomal 40S subunit protein S9A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast tRNA-splicing endonuclease is a heterotrimeric enzyme. Rauhut R, et al. J Biol Chem, 1990 Oct 25. PMID 2211694
    2. The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases. Trotta CR, et al. Cell, 1997 Jun 13. PMID 9200603
    3. The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localized CBP1 mRNA. Tsuboi T, et al. J Biol Chem, 2015 Jun 26. PMID 25971974, Free PMC Article
    4. Exon structure requirements for yeast tRNA ligase. Liu J, et al. Sci China C Life Sci, 1997 Dec. PMID 18726292
    5. Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria. Yoshihisa T, et al. Mol Biol Cell, 2003 Aug. PMID 12925762, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to tRNA-intron endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA-intron endonuclease complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA splicing endonuclease subunit SEN54
    NP_015242.1
    • Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      396702..398105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183897.1 → NP_015242.1  TPA: tRNA splicing endonuclease subunit SEN54 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3T4, Q02825
      UniProtKB/TrEMBL
      A0A6A5Q708, A6ZWG8, C8ZIU7, N1P1N0
      Conserved Domains (1) summary
      pfam12928
      Location:75 → 144
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02825.1

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