SER1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SER1
Primary source: FungiDB:YOR184W
Locus tag: YOR184W
See related: SGD:S000005710; AllianceGenome:SGD:S000005710; VEuPathDB:YOR184W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADE9
Summary: Enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity. Involved in L-serine biosynthetic process and purine nucleobase biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-serine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-serine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-serine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serine family amino acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

NP_014827.3

3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress

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The following sections contain reference sequences that belong to a specific genome build. Explain