SMI1 Smi1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SMI1
Official Full Name: Smi1p
Primary source: SGD:S000003461
Locus tag: YGR229C
See related: AllianceGenome:SGD:S000003461; FungiDB:YGR229C; VEuPathDB:YGR229C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KNR4
Summary: Predicted to enable DNA binding activity. Involved in regulation of fungal-type cell wall biogenesis and regulation of mitotic cell cycle. Located in cellular bud neck. Part of incipient cellular bud site. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SMI1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (949382..950899, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Saccharomyces cerevisiae CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy.
Title: Saccharomyces cerevisiae CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy.
The Conserved Yeast Protein Knr4 Involved in Cell Wall Integrity Is a Multi-domain Intrinsically Disordered Protein.
Title: The Conserved Yeast Protein Knr4 Involved in Cell Wall Integrity Is a Multi-domain Intrinsically Disordered Protein.
Loss of Smi1, a protein involved in cell wall synthesis, extends replicative life span by enhancing rDNA stability in Saccharomyces cerevisiae.
Title: Loss of Smi1, a protein involved in cell wall synthesis, extends replicative life span by enhancing rDNA stability in Saccharomyces cerevisiae.
Dysfunctional (mutant) Knr4 protein playing the role of the transcriptional regulator of cell wall chitin and glucan synthesis, the Lifespan increased significantly.
Title: Cell wall biosynthesis impairment affects the budding lifespan of the Saccharomyces cerevisiae yeast.
Knr4 has been shown to engage in multiple physical interactions, an ability conferred by the intrinsic structural adaptability of major disordered regions present in the N-terminal and C-terminal parts of the protein. [REVIEW]
Title: Knr4: a disordered hub protein at the heart of fungal cell wall signalling.
crystal structure of structured core domain of Knr4
Title: Crystallographic studies of the structured core domain of Knr4 from Saccharomyces cerevisiae.
The authors show that the N-terminal domain is required for the proper cellular localization of Knr4 at sites of polarized growth during vegetative growth and sexual differentiation (bud tip and 'shmoo' tip).
Title: Knr4 N-terminal domain controls its localization and function during sexual differentiation and vegetative growth.
Computational analysis supported by biochemical and biophysical data characterize Knr4 as a newly identified member of the growing family of intrinsically disordered proteins
Title: Structure-function analysis of Knr4/Smi1, a newly member of intrinsically disordered proteins family, indispensable in the absence of a functional PKC1-SLT2 pathway in Saccharomyces cerevisiae.
Knr4 is a regulatory protein that participates in the coordination of cell wall synthesis with bud emergence, and that this function may be modulated by phosphorylation of this protein
Title: The 'interactome' of the Knr4/Smi1, a protein implicated in coordinating cell wall synthesis with bud emergence in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell wall biogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall beta-glucan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of fungal-type cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of fungal-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Smi1p

NP_011745.1

Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

949382..950899 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181358.1 → NP_011745.1 TPA: Smi1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011745.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV09, P32566

UniProtKB/TrEMBL

B5VJG7, C7GNK0, N1P4C8

Conserved Domains (2) summary

PTZ00121
Location:329 → 501

PTZ00121; MAEBL; Provisional

COG4282
Location:84 → 308

SMI1; Cell wall assembly regulator SMI1 [Cell wall/membrane/envelope biogenesis]