SMY1 Smy1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SMY1
Official Full Name: Smy1p
Primary source: SGD:S000001562
Locus tag: YKL079W
See related: AllianceGenome:SGD:S000001562; FungiDB:YKL079W; VEuPathDB:YKL079W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cytoskeletal motor activity. Involved in vesicle docking involved in exocytosis. Located in cellular bud neck; cellular bud tip; and mating projection tip. Part of incipient cellular bud site. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking involved in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mating projection tip	HDA more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

NP_012844.1

Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics

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The following sections contain reference sequences that belong to a specific genome build. Explain