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    SNX4 Snx4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853416, updated on 6-Oct-2024

    Summary

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    Official Symbol
    SNX4
    Official Full Name
    Snx4p
    Primary source
    SGD:S000003573
    Locus tag
    YJL036W
    See related
    AllianceGenome:SGD:S000003573; FungiDB:YJL036W; VEuPathDB:YJL036W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ATG24; CVT13
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including endosomal transport; piecemeal microautophagy of the nucleus; and protein localization to organelle. Located in cytosol; early endosome; and phagophore assembly site. Is extrinsic component of membrane. Orthologous to several human genes including SNX30 (sorting nexin family member 30). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SNX4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (378825..380096)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Irc18p Neighboring gene tRNA-Val Neighboring gene tRNA(adenine34) deaminase Neighboring gene Hsp70 family ATPase KAR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SORTING NEXIN 1 Functions in Plant Salt Stress Tolerance Through Changes of NO Accumulation by Regulating NO Synthase-Like Activity. Li TT, et al. Front Plant Sci, 2018. PMID 30542353, Free PMC Article
    2. Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction. Popelka H, et al. Proc Natl Acad Sci U S A, 2017 Nov 21. PMID 29114050, Free PMC Article
    3. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. Nice DC, et al. J Biol Chem, 2002 Aug 16. PMID 12048214, Free PMC Article
    4. Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4. Nemec AA, et al. J Biol Chem, 2017 Dec 29. PMID 29109144, Free PMC Article
    5. Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. Strochlic TI, et al. J Cell Biol, 2007 Apr 9. PMID 17420293, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in early endosome to Golgi transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in early endosome to Golgi transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to endosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Snx4p
    NP_012498.1
    • Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      378825..380096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181470.1 → NP_012498.1  TPA: Snx4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012498.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWE7, P47057, Q06794
      UniProtKB/TrEMBL
      A6ZPU0, B3LQ75, C7GSQ8, C8ZBH7, G2WGY2, N1P1C9
      Conserved Domains (1) summary
      COG5391
      Location:1 → 423
      COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47057.1

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